Patterns of Integrin Expression

There are three typical patterns:

1. Beta-3 integrin POSITIVE with an “in-phase” endometrium from cycle days 20–24 (7–11 days post LH surge) is a normal pattern of expression.

2. Beta-3 integrin NEGATIVE with an “out-of-phase” endometrium occurs in a patient with Luteal Phase Defect; following treatment the patient is advised to undergo a repeat biopsy to confirm diagnosis.1

3. Beta-3 integrin NEGATIVE in a patient with a normal “in phase” endometrium is associated with unexplained infertility,1 minimal or mild endometriosis,2 or hydrosalpinx. 3

The E-tegrity test:

  • Identifies endometrial quality
  • Determines Beta-3 integrin presence
  • Provides a histologic evaluation of the endometrium
Endometrial Cycle
Positive
Negative

 

Sample Collection

Endometrial quality is identified during the window of implantation. It is crucial that the patient have a carefully timed endometrial biopsy. The specimen must be collected on cycle days 20–24 (7–11 days post LH surge).

The biopsy must be sent to Innovative Reproductive Solutions, the only licensed provider of the E-tegrity Test.

 

1 Lessey BA, Castlebaum AJ, Sawin SW, Sun J. Integrins as markers of uterine receptivity in women with primary unexplained infertility. Fertil Steril 1995; 63:535-42.

2 Lessey BA, Castlebaum AJ, Sawin SW, Buck CA, Schinnar R, Bilker W, Strom BL. Abberant integrin expression in the endometrium of women with endometriosis. J Clin Endocrinol Metab 1994; 79:643-9.

3 Meyer, Castlebaum AJ, Somkuti S, Sagoskin AW, Doyle M, Harris JE, Lessey BA. Hydrosalpignes adversely affect markers of endometrial receptivity. Human Rep 1997; 12:1393-8.